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Mitochondrial abnormalities in NAFLD Mitochondrial dysfunction plays a pivotal role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

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In brief, the loss of protein content in skeletal muscle is the result not only of the activation of several pro-catabolic stimuli (such as Interleukin-6, Interleukin-1, Tumor Necrosis Factor-, Myostatin etc.) but also of the absence or reduction of pro-anabolic signals (such as Growth Hormone, Insulin, Insulin-like Growth Factor-1, sexual hormones etc.)